What is CBD, Cannabidiol?
Cannabidiol is a chemical compound derived from the Cannabis sativa plant. Over 80 compound chemicals, known as cannabinoids, have been identified in the Cannabis sativa plant. The most popular, delta-9-tetrahydrocannabinol (THC), is known for its euphoria and intoxicating effects. Whereas Cannabidiol does not create a stimulant or high.
Sativa Valley’s Cannabidiol
Here at Sativa Valley, we use a highly concentrated, pure form of cannabidiol commonly referred to as CBD Isolate. Cannabidiol in its Isolate form allows us to create potent CBD recipes which are free from all other cannabinoids (including THC.) This ensures all of our customers can safely use our products and receive the same, consistent serving size of CBD each time. All of our customers are guaranteed not to fail a drug screening due to the presence of THC in our products, as all of our CBD Isolate and the products themselves are tested by an independent third party laboratory testing facility. For the latest COA (Certificate of Analysis) on our Cannabidiol or one of our products, please email or contact us via phone!
Cannabidiol and the Human Body
Cannabinoid receptors are involved in a series of processes inside the human body, including the regulation of mood, pain sensation, appetite and memory.These receptors can be activated by endocannabinoids (produced by the human body) as well as by plant cannabinoids (like those found in hemp or cannabis), and they’re grouped into two main categories: CB1 and CB2. CB1 receptors are found mostly in the central nervous system, and in smaller numbers in the liver, kidneys and lungs, while CB2 receptors are part of the immune system and found in the hematopoietic blood cells as well.
Activating Adjacent Receptors
CBD does not stimulate these two receptors; instead, it activates other receptors, like the vanilloid, adenosine and serotonin receptors. By activating the TRPV-1 receptor for example, cannabidiol plays a role in the mediation of body temperature, pain perception and inflammation. Then, CBD inhibits the FAAH enzyme, a compound that activates the CB1 receptor. By doing so, CBD minimizes the activation of CB1 by THC, reducing its psychoactive effects.
The activation of adenosine receptors by CBD gives the anti-anxiety and anti-inflammatory effects of cannabidiol. Adenosine receptors are also involved in the release of dopamine and glutamate, two neurotransmitters that play major roles inside the body. Dopamine is involved in cognition, motor control, motivation and reward mechanisms, while glutamate is one of the major mediators of excitatory signals, being involved in memory, learning and cognition.
Blocking & Passing, Cannabidiol Across the Body
High concentrations of CBD have been shown to activate the 5-HT1A serotonin receptor, exerting anti-depressant effects. The same receptor is involved in a series of processes from pain perception, appetite, nausea and anxiety to sleep and addiction mechanisms. Finally, CBD blocks CPR55 signaling, decreasing bone re-absorption and cell proliferation. GPR55 is widely present inside the brain, being linked with the modulation of bone density and blood pressure, as well as with cell proliferation.
As previously said, CBD blocks the psychoactive action of THC, this being one of the reasons it’s generally considered advantageous to combine CBD and THC when for treatment purposes. However, the positive effects of cannabidiol are not dependent on the presence of THC, so you can still take advantage of the health benefits of CBD by purchasing products that contain only non-psychoactive CBD.
Curious about current scientific information about CBD? Here are a few great resources on Cannabidiol we rely on.