• Alprazolam (Xanax). Taking ginkgo with this drug used to relieve symptoms of anxiety might reduce the drug's effectiveness.
  • Anticoagulants and anti-platelet drugs, herbs and supplements. These types of drugs, herbs and supplements reduce blood clotting. Taking ginkgo with them might increase your risk of bleeding.
  • Anti-convulsants and seizure threshold lowering drugs, herbs and supplements. Large amounts of ginkgo-toxin can cause seizures. Ginkgo-toxin is found in ginkgo seeds and, to a lesser extent, ginkgo leaves. It's possible that taking ginkgo could reduce the effectiveness of an anti-convulsant drug.
  • Antidepressants. Taking ginkgo with certain antidepressants, such as fluoxetine (Prozac, Sarafem) and imipramine (Tofranil), might decrease their effectiveness.
  • Certain statins. Taking ginkgo with simvastatin (Zocor) might reduce the drug's effects. Ginkgo also appears to reduce the effects of atorvastatin (Lipitor).
  • Diabetes drugs. Ginkgo might alter your response to these drugs.
  • Ibuprofen. It's possible that combining ginkgo with ibuprofen (Advil, Motrin IB, others) might increase your risk of bleeding.